Effective stabilisation of alpha-helical structures in short peptides with acetylenic cross-linking agents.

Supplementary Information General Materials. The starting materials were all commercially available, and 1,4-bis(2hydroxyethoxy)-2-butyne (5b) and 2,4-hexadiyne-1,6-diol (8) were prepared according to the literature procedures. The cross-linking agents 3a, 3b, and 4b were reported previously, however, the physical and spectroscopic data of 4b were not described in the literature and were presented in this Supplementary Information.